Korean J Ophthalmol.  1995 Dec;9(2):84-88. 10.3341/kjo.1995.9.2.84.

Ultrastructural change of the Muller cell in the culture of sensory retina

• Song BJ
• Ko MK
• Choe JK

• KMID: 1735142
• DOI: http://doi.org/10.3341/kjo.1995.9.2.84

Abstract

This study was performed to investigate the sequential changes of the retinal tissue in tissue culture condition. The human sensory retinal tissues were cultured for up to 2 weeks and 4 weeks, respectively. The initial changes showed the separation of the intercellular space and the consequent widening of the intercellular space with prolapse of cytoplasmic processes into the widened intercellular space. The internal limiting membrane was also separated from the inner retina, which led to the prolapse of the cytoplasm of the Muller cell. The growth of the Muller cell was most prominent during the 4-weeks' tissue culture period. These findings suggest that the Muller cell might contribute to the formation of cellular membrane in case of the defect of the internal limiting membrane in several pathologic conditions.

Keyword

Muller cell; preretinal membrane; sensory retina; tissue culture

MeSH Terms

Adult
Cell Membrane/ultrastructure
Cells, Cultured
Humans
Male
Middle Aged
Neuroglia/*ultrastructure
Retina/*ultrastructure