Korean J Ophthalmol.  1993 Jun;7(1):28-33. 10.3341/kjo.1993.7.1.28.

Effect of apraclonidine hydrochloride on the attack of Posner-Schlossman syndrome

• Hong C
• Song KY

• KMID: 1735107
• DOI: http://doi.org/10.3341/kjo.1993.7.1.28

Abstract

The intraocular pressure (IOP) of glaucomatocyclitic crisis with the attack fell 50.3%, from 37.8 +/- 8.2 mmHg to 18.8 +/- 4.8 mmHg, 4 hours after instillation of 1% apraclonidine. Glaucomatocyclitic crisis showed a more significant hypotensive response to 1% apraclonidine than primary open-angle glaucoma (24.8%, from 43. 1 +/- 8.1 mmHg to 32.4 +/- 7.5 mmHg after 4 hours). The intraocular pressure decrease percentage was similar regardless of the initial level of intraocular pressure. Clinically significant changes in mean systolic and diastolic blood pressures, were not observed, however, a mild decrease in the pulse rate was noted. And the local mydriatic effect on the pupillary diameter was significant. Apraclonidine, 1% might be newly indicated to control the IOP rise of glaucomatocyclitic crisis. Further studies on the possible mechanism of the prostaglandin mediated hypotensive effect of 1% apraclonidine are suggested.

Keyword

apraclonidine; glaucomatocyclitic crisis; intraocular pressure; primaryopen-angle glaucoma

MeSH Terms

Adolescent
Adrenergic alpha-Agonists/*administration & dosage
Adult
Aged
Clonidine/administration & dosage/*analogs & derivatives
Female
Glaucoma, Open-Angle/drug therapy
Hemodynamics
Humans
Intraocular Pressure
Iridocyclitis/*drug therapy
Male
Middle Aged
Ocular Hypertension/*drug therapy
Ophthalmic Solutions
Syndrome
Adrenergic alpha-Agonists
Clonidine
Ophthalmic Solutions