Yonsei Med J.  2005 Apr;46(2):233-238. 10.3349/ymj.2005.46.2.233.

Assisted Cough and Pulmonary Compliance in Patients with Duchenne Muscular Dystrophy

• Kang SW
• Kang YS
• Moon JH
• Yoo TW

• KMID: 1734049
• DOI: http://doi.org/10.3349/ymj.2005.46.2.233

Abstract

The aim of this study was to investigate the factors affecting cough ability, and to compare the assisted cough methods in patients with Duchenne muscular dystrophy (DMD). A total seventy-one male patients with DMD were included in the study. The vital capacity (VC) and maximum insufflation capacity (MIC) were measured. The unassisted peak cough flow (UPCF) and three different techniques of assisted peak cough flow were evaluated. UPCF measurements were possible for all 71 subjects. But when performing the three different assisted cough techniques, peak cough flows (PCFs) could be obtained from only 51 subjects. The mean value of MICs (1801+/-780cc) was higher than that of VCs (1502+/-765cc) (p< 0.01). All three assisted cough methods showed a significantly higher value than the unassisted method (F=80.92, p< 0.01). The manual assisted PCF under MIC (MPCFmic) significantly exceeded those produced by manual assisted PCF (MPCF) or PCF under MIC (PCFmic). The positive correlation between the MIC, VC difference (MIC-VC), and the difference between PCFmic and UPCF (PCFmic-UPCF) was seen (r= 0.572, p< 0.01). The preservation of pulmonary compliance is important for the development of an effective cough as well as assisting the compression and expulsive phases. Thus, the clinical importance of the inspiratory phase and pulmonary compliance in assisting a cough should be emphasized.

Keyword

Assisted cough; maximum insufflation capacity; peak cough flow; pulmonary compliance

MeSH Terms

Adolescent
Child
Cough/*physiopathology
Humans
Inspiratory Capacity
*Lung Compliance
Male
Muscular Dystrophy, Duchenne/*physiopathology/*therapy
Pulmonary Ventilation
*Respiratory Therapy
Vital Capacity

Figure

• 

  Fig. 1 Relationship between the MIC, VC difference (MIC-VC), and the difference between PCFmic and UPCF (PCFmic-UPCF). The MIC-VC correlated significantly with the PCFmic-UPCF (r=0.572; p < 0.01). MIC, maximum insufflation capacity; VC, vital capacity; PCFmic, peak cough flow under maximum insufflation capacity; UPCF, unassisted peak cough flow.

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