J Korean Med Sci.  2004 Oct;19(5):674-676. 10.3346/jkms.2004.19.5.674.

Pattern of Recurrence after Curative Resection of Local (Stage I and II) Non-Small Cell Lung Cancer: Difference According to the Histologic Type

• Choi YS
• Shim YM
• Kim K
• Kim J

• KMID: 1733507
• DOI: http://doi.org/10.3346/jkms.2004.19.5.674

Abstract

The aim of the present study was to evaluate the pattern of recurrence after complete resection of pathological stage I, II non-small cell lung cancer, especially according to the cell type. We reviewed the clinical records of 525 patients operated on for pathologic stage I and II lung cancer. The histologic type was found to be squamous in 253 and non-squamous in 229 patients. Median follow-up period was 40 months. Recurrences were identified in 173 (36%) of 482 enrolled patients; distant metastasis in 70%, distant and local recurrence in 11%, and local recurrence in 19%. Distant metastasis was more common in non-squamous than in squamous cell carcinoma (p=0.044). Brain metastasis was more frequently identified in non-squamous mthan in squamous cell carcinoma (24.2% vs. 7.3%. p=0.005). Multivariate analyses showed that cell type is the significant risk factor for recurrence-free survival in stage I and stage II non-small cell lung cancer. Recurrence-free survival curves showed that non-squamous cell carcinoma had similar risks during early periods of follow-up and more risks after 2 yr from the operation compared to squamous cell carcinoma. Pathological stage and histologic type significantly influence recurrence-free survival.

Keyword

Carcinoma, Non-Small-Cell Lung; Pneumonectomy; Neoplasm Recurrence, Local

MeSH Terms

Brain Neoplasms/mortality/secondary
Carcinoma, Non-Small-Cell Lung/*mortality/*pathology/surgery
Carcinoma, Squamous Cell/mortality/pathology/surgery
Disease-Free Survival
Female
Follow-Up Studies
Humans
Lung Neoplasms/*mortality/*pathology/surgery
Male
Middle Aged
Neoplasm Recurrence, Local/mortality/pathology
Neoplasm Staging/*mortality
Pneumonectomy
Risk Factors
Survival Analysis

Figure

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  Fig. 1 Recurrence-free survival according to the cell type in stage I patients.

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  Fig. 2 Recurrence-free survival according to the cell type in stage II patients.

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