J Korean Med Sci.  2004 Oct;19(5):652-655. 10.3346/jkms.2004.19.5.652.

The Usefulness of Surface Electrocardiogram as a Prognostic Predictor in Children with Idiopathic Dilated Cardiomyopathy

Affiliations
  • 1Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
  • 2Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea. chungnoh@snu.ac.kr

Abstract

We investigated the interrelations between surface electrocardiographic changes and clinical outcomes in children with idiopathic dilated cardiomyopathy (DCMP). 33 patients (19 boys, 14 girls) were classified into two groups; group I (15) who were in poor clinical status or dead; and group II (18) who showed good clinical status. Group I had larger LV dimensions compared to group II (Gr I vs. Gr II; LVEDD, 52 +/-11 vs. 42+/-7 (mm); LVESD, 43+/-12 vs. 30+/-5 (mm); p<0.05). QRS duration was prolonged in Gr I compared to Gr II and normal (Gr I, 84+/-28; Gr II, 66+/-12; normal control, 67+/-9). The QRS duration was correlated with the dimensions of left ventricle (LV). Corrected QT and JT interval and dispersions of QT in the DCMP group showed a significant difference compared to the normal control, however there was no significant difference between Gr I and II. In conclusion, QRS duration was correlated with ventricular dimension and clinical outcome in children with idiopathic dilated cardiomyopathy. Irrespective of increased ventricular inhomogeneity, QT dispersion could not be used to predict long-term prognosis.

Keyword

Dilated Cardiomyopathy; Cardiomyopathy, Congestive; Child; Electrocardiography; QT Dispersion; QRS Duration

MeSH Terms

Cardiomyopathy, Dilated/*diagnosis/*mortality
Child
Child, Preschool
*Electrocardiography
Electrodes
Female
Humans
Infant
Male
Predictive Value of Tests
Prognosis
Retrospective Studies

Figure

  • Fig. 1 Correlation of left ventricular enddiastolic dimension (LVEDD) and QRS duration.

  • Fig. 2 Correlation of left ventricular endsystolic dimension (LVESD) and QRS duration.


Reference

1. De Maria R, Gavazzi A, Caroli A, Ometto R, Biagini A, Camerini F. Ventricular arrhythmias in dilated cardiomyopathy as an independent prognostic hallmark. Italian Multicenter Cardiomyopathy Study (SPIC) Group. Am J Cardiol. 1992. 69:1451–1457.
2. Bjarnason I, Hardarson T, Jonsson S. Cardiac arrhythmias in hypertrophic cardiomyopathy. Br Heart J. 1982. 48:198–203.
Article
3. Kjekshus J. Arrhythmias and mortality in congestive heart failure. Am J Cardiol. 1990. 65:42–48.
Article
4. Greenwood RD, Nadas AS, Fyler DC. The clinical course of primary myocardial disease in infants and children. Am Heart J. 1976. 92:549–560.
Article
5. Taliercio CP, Seward JB, Driscoll DJ, Fisher LD, Gersh BJ, Tajik AJ. Idiopathic dilated cardiomyopathy in the young: clinical profile and natural history. J Am Coll Cardiol. 1985. 6:1126–1131.
Article
6. Griffin ML, Hernandez A, Martin TC, Goldring D, Bolman RM, Spray TL, Strauss AW. Dilated cardiomyopathy in infants and children. J Am Coll Cardiol. 1988. 11:139–144.
Article
7. Friedman RA, Moak JP, Garson A Jr. Clinical course of idiopathic dilated cardiomyopathy in children. J Am Coll Cardiol. 1991. 18:152–156.
Article
8. Vermeulen JT. Mechanisms of arrhythmias in heart failure. J Cardiovasc Electrophysiol. 1998. 9:208–221.
Article
9. Xiao HB, Roy C, Fujimoto S, Gibson DG. Natural history of abnormal conduction and its relation to prognosis in patients with dilated cardiomyopathy. Int J Cardiol. 1996. 53:163–170.
Article
10. de Bakker JM, van Capelle FJ, Janse MJ, Wilde AA, Coronel R, Becker AE, Dingemans KP, van Hemel NM, Hauer RN. Reentry as a cause of ventricular tachycardia in patients with chronic ischemic heart disease: electrophysiologic and anatomic correlation. Circulation. 1988. 77:589–606.
Article
11. Aronson RS. Afterpotentials and triggered activity in hypertrophied myocardium from rats with renal hypertension. Circ Res. 1981. 48:720–727.
Article
12. Beuckelmann DJ, Nabauer M, Erdmann E. Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure. Circulation. 1992. 85:1046–1055.
Article
13. Pierpont GL, Francis GS, DeMaster EG, Olivari MT, Ring WS, Goldenberg IF, Reynolds S, Cohn JN. Heterogeneous myocardial catecholamine concentrations in patients with congestive heart failure. Am J Cardiol. 1987. 60:316–321.
Article
14. Beau SL, Tolley TK, Saffitz JE. Heterogeneous transmural distribution of beta-adrenergic receptor subtypes in failing human hearts. Circulation. 1993. 88:2501–2509.
Article
15. Dargie HJ, Cleland JG, Leckie BJ, Inglis CG, East BW, Ford I. Relation of arrhythmias and electrolyte abnormalities to survival in patients with severe chronic heart failure. Circulation. 1987. 75(5 Pt 2):IV98–IV107.
16. Coronel R, Fiolet JW, Wilms-Schopman FJ, Schaapherder AF, Johnson TA, Gettes LS, Janse MJ. Distribution of extracellular potassium and its relation to electrophysiologic changes during acute myocardial ischemia in the isolated perfused porcine heart. Circulation. 1988. 77:1125–1138.
Article
17. Pye MP, Cobbe SM. Arrhythmogenesis in experimental models of heart failure: The role of increased load. Cardiovasc Res. 1996. 32:248–257.
Article
18. Vassallo JA, Cassidy DM, Kindwall KE, Marchlinski FE, Josephson ME. Nonuniform recovery of excitability of the left ventricle. Circulation. 1988. 78:1365–1372.
19. Zaidi M, Robert A, Fesler R, Derwael C, Brohet C. Dispersion of ventricular repolarization in hypertrophic cardiomyopathy. J Electrocardiol. 1996. 29:Suppl. 89–94.
Article
20. Martin AB, Garson A Jr, Perry JC. Prolonged QT interval in hypertrophic and dilated cardiomyopathy in children. Am Heart J. 1994. 127:64–70.
Article
21. Barr CS, Naas A, Freeman M, Lang CC, Struthers AD. QT dispersion and sudden unexpected death in chronic heart failure. Lancet. 1994. 343:327–329.
Article
22. Pinsky DJ, Sciacca RR, Steinberg JS. QT dispersion as a marker of risk in patients awaiting heart transplantation. J Am Coll Cardiol. 1997. 29:1576–1584.
Article
23. Davey PP, Bateman J, Mulligan IP, Forfar C, Barlow C, Hart G. QT interval dispersion in chronic heart failure and left ventricular hypertrophy: relation to autonomic nervous system and Holter tape abnormalities. Br Heart J. 1994. 71:268–273.
Article
24. Fei L, Goldman JH, Prasad K, Keeling PJ, Reardon K, Camm AJ, McKenna WJ. QT dispersion and RR variations on 12 lead ECGs in patients with congestive heart failure secondary to idiopathic dilated cardiomyopathy. Eur Heart J. 1996. 17:258–263.
25. Zaidi M, Robert A, Fesler R, Derwael C, Brohert C. Dispersion of ventricular repolarization in dilated cardiomyopathy. Eur Heart J. 1997. 18:1129–1134.
Article
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