J Korean Med Sci.  1999 Aug;14(4):455-459. 10.3346/jkms.1999.14.4.455.

Colonic adenocarcinoma metastatic to the thyroid gland: a case report with immunohistochemical investigation

• Kim CH
• Park YW
• Ayala AG
• Ro JY

• KMID: 1731323
• DOI: http://doi.org/10.3346/jkms.1999.14.4.455

Abstract

Clinically evident metastases of carcinomas to the thyroid gland are rare, particularly from a colorectal primary tumor. We present a case of colonic adenocarcinoma metastatic to the thyroid gland with histopathologic and immunohistochemical findings. A 68-year-old woman with a history of Dukes' stage B colon carcinoma presented a mass in the thyroid gland. The tumor was confirmed to be metastatic adenocarcinoma from the colon. The immunohistochemical findings demonstrated positive staining for cytokeratin 20, low-molecular-weight cytokeratin, villin and carcinoembryonic antigen, but stains were negative for cytokeratin 7 and thyroglobulin.

Keyword

Adenocarcinoma; Neoplasm metastasis; Immunohistochemistry; Thyroid gland

MeSH Terms

Adenocarcinoma/secondary*
Adenocarcinoma/radiography
Aged
Carcinoembryonic Antigen/analysis
Carrier Proteins/analysis
Case Report
Colonic Neoplasms/pathology*
Female
Human
Immunoenzyme Techniques
Intermediate Filament Proteins/analysis
Keratin/analysis
Microfilament Proteins/analysis
Thyroid Neoplasms/secondary*
Thyroid Neoplasms/radiography
Thyroid Nodule/radiography
Thyroid Nodule/chemistry
Tomography, X-Ray Computed
Tumor Markers, Biological