J Korean Med Sci.  2000 Aug;15(4):420-424. 10.3346/jkms.2000.15.4.420.

Glucose transporter 1 (GLUT1) expression is associated with intestinal type of gastric carcinoma

• Kim WS
• Kim YY
• Jang SJ
• Kimm K
• Jung MH

• KMID: 1730638
• DOI: http://doi.org/10.3346/jkms.2000.15.4.420

Abstract

Increased expression of glucose transporter1 (GLUT1) has been reported in many human cancers. We hypothesized that the degree of GLUT1 might provide a useful biological information in gastric adenocarcinoma. RT-PCR and immunostaining were used to analyze GLUT1 expression in gastric cancer. RT-PCR showed GLUT1 expression was not largely detected in normal gastric tissue but was detected in cancerous gastric tissue of counterpart. By immunohistochemistry, GLUT1 protein was absent in normal gastric epithelium and intestinal metaplasia. 11 of 65 patients with gastric adenocarcinoma had specific GLUT1 immunostaining in a plasma membrane pattern with varied intensities. GLUT1 protein did not show any significant correlation with tumor stage and nodal metastasis (p+AD4-0.05 by Mann-Whitney test). However, the positive immunostaining for GLUT1 is associated with intestinal differentiation (p+AD0-0.003). Our results suggest that GLUT1 protein is associated with intestinal type of gastric cancer.

Keyword

Monosaccharide Transport Proteins; Stomach Neoplasms; Prognosis

MeSH Terms

Adenocarcinoma/pathology
Adenocarcinoma/chemistry+ACo-
Adult
Aged
Female
Gastric Mucosa/pathology
Gastric Mucosa/chemistry+ACo-
Human
Intestines
Male
Metaplasia
Middle Age
Monosaccharide Transport Proteins/analysis+ACo-
Neoplasm Proteins/analysis+ACo-
Reverse Transcriptase Polymerase Chain Reaction
Stomach Neoplasms/pathology
Stomach Neoplasms/chemistry+ACo-
Tumor Markers, Biological/analysis+ACo-