Yonsei Med J.  1988 Sep;29(3):270-277. 10.3349/ymj.1988.29.3.270.

A Case of Vitamin B12 Deficiency Megaloblastic Anemia Following Total Gastrectomy

• Hahn JS
• Nam DK
• Lee EJ
• Lee SJ
• Ko YW
• Sunwoo IN
• Lee KS

• KMID: 1729558
• DOI: http://doi.org/10.3349/ymj.1988.29.3.270

Abstract

Megaloblastic anemia following gastrectomy is due to the total absence or inadequate secretion of intrinsic factor and is manifested by megalobastic changes in bone marrow, blood cells, and other proliferative cells. In Korea, detailed description and precise analyses of the cases of megaloblastic anemia following gastrectomy are relatively rare in contrast to the potential of its incidence from gastrectomy due to many causes or to the importance of its clinical significance. Here, we present the case of a 51-year old man who had undergone a total gastrectomy with esophagojejunostomy and incidental splenectomy due to early gastric cancer and developed megalobastic anemla 7 years after surgery. After gradual improvement of clinical and hematologic features with treatment of parenteral vltamin Bl2, he was followed-up with vitamin B12 maintenance therapy.

Keyword

Megaloblastic anemia; total gastrectomy; neuropathy; intrinsic factor; vitamin B12 deficiency

MeSH Terms

Anemia, Macrocytic/*etiology
Anemia, Megaloblastic/diagnosis/*etiology
Case Report
Gastrectomy/*adverse effects
Human
Male
Middle Age
Vitamin B 12 Deficiency/*etiology