Korean J Pediatr Hematol Oncol.  2004 Apr;11(1):97-101.

Two Cases of Megaloblastic Anemia Induced by Vitamin B12 Deficiency in Children

• Kim JY
• Kim BM
• Lee KS

Abstract

Megaloblastic anemia induced by Vitamin B12 deficiency is a disorder caused by impaired DNA synthesis. It has been previously thought to be rare in children, however, recent studies suggest that this condition is more common than previously recognized. Deficiency can lead to a wide spectrum of hematologic and neuropsychiatric disorders. Especially in children, it often presents with nonspecific manifestations, such as developmental delay, irritability, weakness, and failure to thrive. Early diagnosis and prompt treatment might resolve these complications, but permanent neurologic damage may have already occurred. We experienced two cases of Megaloblastic Anemia induced by Vitamin B12 deficiency and report them with a brief review of the literature.

Keyword

Megaloblastic anemia; Vitamin B12 deficiency; Chidren

MeSH Terms

Anemia, Megaloblastic*
Child*
DNA
Early Diagnosis
Failure to Thrive
Humans
Megaloblasts*
Vitamin B 12 Deficiency*
Vitamin B 12*
Vitamins*
DNA
Vitamin B 12
Vitamins