Yonsei Med J.  1994 Sep;35(3):314-319. 10.3349/ymj.1994.35.3.314.

Antimicrobial susceptibility of Campylobacter fetus subsp. fetus isolated from blood and synovial fluid

• Kwon SY
• Cho DH
• Lee SY
• Lee K
• Chong Y

• KMID: 1728916
• DOI: http://doi.org/10.3349/ymj.1994.35.3.314

Abstract

Campylobacter fetus subsp. fetus is a rare human pathogen, but can cause serious extraintestinal infections. Effective antimicrobial agent is required for the therapy, but we have very limited knowledge on the susceptibility of the organism. In this study, the susceptibility of 25 isolates of the organism to 14 antimicrobial agents was tested by an agar dilution method. Antimicrobial agents with low MIC ranges, in micrograms/ml, were: meropenem Y or = 0.25, dirithromycin < or = 0.5, gentamicin > or = 1, amikacin, ofloxacin, tetracycline and erythromycin < or = 2. The MIC range of cefepime was 0.5-8 micrograms/ml, but those of other beta-lactams were relatively high. All of the isolates were interpreted to be susceptible to cefepime, meropenem, amikacin, gentamicin, ofloxacin, tetracycline and dirithromycin. A significant proportion of the isolates were either intermediate or resistant to ampicillin, cephalothin, cefotaxime, aztreonam, loracarbef and erythromycin. In conclusion, the organism remains susceptible to aminoglycosides and tetracycline. Greater in vitro activity of meropenem, ofloxacin and dirithromycin require clinical evaluation.

Keyword

Campylobacter fetus subsp; fetus, antimicrobial susceptibility; agar dilution test

MeSH Terms

Antibiotics/*pharmacology
Blood/*microbiology
Campylobacter fetus/*drug effects/isolation & purification
Human
Microbial Sensitivity Tests
Synovial Fluid/*microbiology