Korean J Vet Res.  2014 Sep;54(3):193-196.

Cerebellar encephalopathy from diminazene aceturate (beneril) toxicity in a dog

Affiliations
  • 1Section of Small Animal Internal Medicine, Institute of Veterinary Science, College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University, Chuncheon 200-701, Korea. hyun5188@kangwon.ac.kr

Abstract

A 2-year old castrated male Alaskan malamute was referred with primary complaints of marked anemia, hemeglobinuria and depression. Laboratory tests revealed canine babesiois with severe anemia. The dog was treated by blood transfusion and beneril (diminazene aceturate, 3.5 mg/kg IM). Two days after Beneril injection, the dog suddenly showed ataxia progressing to paresis. MRI revealed irregularly diffused lesions in the cerebellum. The case was tentatively diagnosed as cerebellar encephalopathy caused by diminazene toxicity. The dog successfully recovered following steroid therapy.

Keyword

beneril; cerebellar ataxia; cerebellar encephalopathy; diminazene aceturate; dog

MeSH Terms

Anemia
Animals
Ataxia
Blood Transfusion
Cerebellar Ataxia
Cerebellum
Depression
Diminazene*
Dogs*
Humans
Magnetic Resonance Imaging
Male
Paresis
Diminazene
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