Yonsei Med J.
2002 Feb;43(1):128-132. 10.3349/ymj.2002.43.1.128.
Successful Treatment of Cisplatin Overdose with Plasma Exchange
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Pochon CHA University, 351 Yatap-dong, Pundang-gu, Sungnam-city, Kyunggi-do 463- 712, Korea. doh@cha.ac.kr
- 2Department of Clinical Pathology, College of Medicine, Pochon CHA University, Sungnam-city, Korea.
- KMID: 1726079
- DOI: http://doi.org/10.3349/ymj.2002.43.1.128
Abstract
- We report a 48-year-old man with laryngeal cancer who received a massive cisplatin toxic overdose without intravenous prehydration through an error in prescription. He received 400 mg/m2 of cisplatin over a 4-day period. On day 4, he exhibited a broad range of cisplatin toxicities and emergency plasma exchange was started. From day 5 through 19, he underwent 9 cycles of plasma exchange and his plasma cisplatin concentration decreased from 2,470 ng/ml to 216 ng/ml. He completely recovered without any sequelae. No previous reports exist in the English literature of survival without complication after the administration of such a high cisplatin dosage without prehydration.
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