Yonsei Med J.  2002 Feb;43(1):25-30. 10.3349/ymj.2002.43.1.25.

Synchrotron Radiation Imaging of Internal Structures in Live Animals

Affiliations
  • 1Yonsei Medical Research Center, C.P.O. Box 8044, Seoul 120-752, Korea. lkh@yumc.yonsei.ac.kr
  • 2Department of Materials Science, Pohang University of Science and Technology, Pohang, Korea
  • 3Department of Radiology, College of Medicine, College of Dentistry, Yonsei University, Seoul, Korea
  • 4Department of Periodontology, College of Medicine, College of Dentistry, Yonsei University, Seoul, Korea
  • 5IPA - Ecole Polytechnique Federale de Lausanne, CH-1015, Lausanne, Switzerland.

Abstract

Ionizing radiation has long been used in medicine since the discovery of X-rays. Diagnostic imaging using synchrotron radiation has been under investigation since Rubenstein et al. reported dual-energy iodine-K-edge subtraction coronary angiography. Recently, computed tomography (CT) and magnetic resonance imaging (MRI) have provided better quality results than conventional radiology, providing important information on human internal structures. However, such techniques are unable to detect fine micron sized structures for the early diagnosis of tumors, vascular diseases and other medical objectives. Third generation synchrotron X-rays are well known for their superiority in coherence and energy tunability with respect to conventional X-rays. Consequently, new contrast mechanisms with a superior spatial resolution are becoming available. Here we present the extremely fine details of live animal internal structures using unmonochromatized synchrotron X-rays (white beam) and a simple detector system. Natural movements of the internal organs are also shown. The results indicate that this imaging technique can be applied to investigating microstructures and evaluating the function of the internal organs. Furthermore, this imaging system may be applied to humans as the next tool beyond CT and MRI.

Keyword

Synchrotron radiation; white beam; imaging technique; phase contrast; internal organ

MeSH Terms

Animal
*Diagnostic Imaging
Male
Mice
Mice, Inbred HRS
*Synchrotrons

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