Korean J Parasitol.  2008 Dec;46(4):293-295. 10.3347/kjp.2008.46.4.293.

Malondialdehyde, Glutathione, and Nitric Oxide Levels in Toxoplasma gondii Seropositive Patients

• Karaman U
• Celik T
• Kiran TR
• Colak C
• Daldal NU

• KMID: 1720600
• DOI: http://doi.org/10.3347/kjp.2008.46.4.293

Abstract

The aim of this study was to investigate the difference in the serum malondialdehyde (MDA), glutathione (GSH), and nitric oxide (NO) levels between normal and T. gondii-infected patients. To this end, MDA, GSH, and NO levels in the sera of 37 seropositive patients and 40 participants in the control group were evaluated. In Toxoplasma ELISA, IgG results of the patient group were 1,013.0 +/- 543.8 in optical density (mean +/- SD). A statistically significant difference was found between patients and the control group in terms of MDA, GSH, and NO levels. A decrease in GSH activity was detected, while MDA and NO levels increased significantly. Consequently, it is suggested that the use of antioxidant vitamins in addition to a parasite treatment shall prove useful. The high infection vs control ratio of MDA and NO levels probably suggests the occurrence as a mechanism of tissue damage in cases of chronic toxoplasmosis. Moreover, it is recommended that the patient levels of MDA, GSH, and NO should be evaluated in toxoplasmosis.

Keyword

Toxoplasma gondii; malondialdehyde; glutathione; nitric oxide

MeSH Terms

Animals
Glutathione/*blood
Humans
Immunity, Cellular
Lipid Peroxidation
Malondialdehyde/*blood
Nitric Oxide/*blood
Oxidative Stress
Toxoplasma
Toxoplasmosis/*blood/immunology