Korean J Parasitol.  2006 Sep;44(3):239-242. 10.3347/kjp.2006.44.3.239.

In vitro protoscolicidal effects of hypertonic glucose on protoscolices of hydatid cyst

Affiliations
  • 1Department of Surgery, Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz 71345-1744, Iran. hoseiniv@sums.ac.ir
  • 2Department of Parasitology and Mycology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71345-1744, Iran.
  • 3Laboratory Animal Research Center/Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71345-1744, Iran.
  • 4GEHRC/Razi Vaccine and Serum Research Institute, School of Medicine, Shiraz University of Medical Sciences, Shiraz 71345-1744, Iran.

Abstract

To evaluate the protoscolicidal effects of various concentrations of hypertonic glucose, live protoscolices of sheep were exposed to 10%, 15%, 25% and 50% glucose solutions. Cetrimide (0.5%), silver nitrate (0.5%) and hypertonic saline (20%) were used as positive controls, while physiological saline was used as a negative control. After 1, 2 and 5 min, the protoscolicidal effects were determined by 1% eosin. A 25% glucose solution had no significant protoscolicidal effect. However, a 50% glucose solution revealed higher protoscolicidal effect than 0.5% silver nitrate but weaker effect than 0.5% cetrimide; the effect was comparable with that of 20% hypertonic saline. The results showed that hypertonic glucose solution is highly effective in killing protoscolices of Echinococcus granulosus in vitro.

Keyword

Echinococcus granulosus; hydatid cyst; protoscolices; protoscolicidal agents; hypertonic glucose solution
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