Korean J Parasitol.
2004 Mar;42(1):7-17. 10.3347/kjp.2004.42.1.7.
Bile duct changes in rats reinfected with Clonorchis sinensis
- Affiliations
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- 1Department of Parasitology and Tropical Medicine, and Institute of Endemic Disease, Seoul National University College of Medicine, Seoul 110-799, Republic of Korea.
- 2Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Republic of Korea.
- 3Department of Parasitology, College of Medicine, Yanbian University, Yanji, Jilin Province 133000, P.R. China.
- KMID: 1720478
- DOI: http://doi.org/10.3347/kjp.2004.42.1.7
Abstract
- This study describes an evaluation of the sonographic, cholangiographic, pathological, and immunological findings, and the protective effect shown by rats reinfected with Clonorchis sinensis. Eight experimental rat groups were, namely, a normal control, a primary infection control, a reinfection I (reinfection 7 week after treatment following 3-week infection), a reinfection II (reinfection 2 week after treatment following 8-week infection), a reinfection III (exploration of the intrahepatic bile ducts 1 week after reinfection 4 week after treatment following 4-week infection), a superinfection, a secondary infection control, and an infection following immunization group. Sonographic and cholangiographic findings showed moderate or marked dilatation of the bile duct confluence in the primary infection control, reinfection II, and secondary infection control groups. Juvenile worms survived in the intrahepatic bile ducts 1 week after reinfection following treatment in the reinfection III group. It was concluded that reinfecting juvenile worms found during the first week following reinfection failed to survive or grow further. Anatomical, pathophysiological, or immunological changes may induce protection from reinfection in rats.
Keyword
MeSH Terms
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Animals
Anthelmintics/administration & dosage/therapeutic use
Antibodies, Helminth/blood
Antigens, Helminth/administration & dosage/immunology
Bile Duct Diseases/parasitology/*pathology/ultrasonography
Bile Ducts, Intrahepatic/parasitology/*pathology/ultrasonography
Cholangiography
Clonorchiasis/parasitology/*pathology/ultrasonography
Clonorchis sinensis/*pathogenicity
Immunization
Praziquantel/administration & dosage/therapeutic use
Rats
Rats, Sprague-Dawley
Sound Spectrography
Support, Non-U.S. Gov't
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