Korean J Parasitol.  1982 Jun;20(1):49-52. 10.3347/kjp.1982.20.1.49.

A case of niclofolan (Bilevon) intoxication

• Hong ST
• Lee SH
• Ahn HS
• Yun CK

• KMID: 1720226
• DOI: http://doi.org/10.3347/kjp.1982.20.1.49

Abstract

The authors reported a case of niclofolan intoxication occurred during the trial of clonorchiasis treatment. The case, a 15 years old Korean schoolboy, took niclofolan(Bilevon) of total 473 mg(11 mg/kg) in 11 divided doses during 20 days. And the case suffered from neurologic symptoms such as severe headache, dizziness, nausea, vomiting, blurred vision, papilledema, retinal hemorrhage, an epsiode of seizure attack and elevated intracranial pressure, and hepatotoxic symptoms such as hepatomegaly, increased serum transaminases, and shoulder pain, excessive sweating and weight loss. Therapy was concentrated to the management of the elevated intracranial pressure. Hepatotoxic manifestations subsided within one month. The clinical signs related to elevated intracranial pressure persisted two months. Body weight regained after 2 months. And the symptoms of headache, dizziness and vomiting were complained intermittently until 4 months after onset. However, no subsequent clinical problems related with this episode has been noted until this record.

MeSH Terms

parasitology-helminth-trematoda
Clonorchis sinensis
clonorchiasis
intoxication
niclofolan
jaundice
weakness
hepatomegaly
headache
intracranial pressure
nausea
vomiting
blurred vision
ocular pain
papilledema
retinal hemorrhage
case report