Korean J Gastroenterol.  2010 Nov;56(5):299-306. 10.4166/kjg.2010.56.5.299.

Comparison between Conventional 4 L Polyethylene Glycol and Combination of 2 L Polyethylene Glycol and Sodium Phosphate Solution as Colonoscopy Preparation

• Lee JW
• Kim N
• Cha BH
• Lee BH
• Hwang TJ
• Jeong YJ
• Choi TH
• Kim HS
• Myung HJ
• Kim J
• Jang JH
• Kim YM
• Kim JY
• Park SW
• Park HK
• Suh S
• Seo PJ
• Song JC
• Shin CM
• Eum YO
• Kwon JH
• Kim JJ
• Song BJ
• Park YS
• Lee DH

• KMID: 1718371
• DOI: http://doi.org/10.4166/kjg.2010.56.5.299

Abstract

BACKGROUND/AIMS
Effective bowel preparation is essential for accurate diagnosis of colon disease. We investigated efficacy and safety of 2 L polyethylene glycol (PEG) solution with 90 mL sodium phosphate (NaP) solution compared with 4 L PEG method.
METHODS
Between August 2009 and April 2010, 526 patients were enrolled who visited Seoul National University Bundang Hospital for colonoscopy. We allocated 249 patients to PEG 4 L group and 277 patients to PEG 2 L with NaP 90 mL group. Detailed questionnaires were performed to investigate compliance, satisfaction and preference of each method. Bowel preparation quality and segmental quality were evaluated. Success was defined as cecal intubation time less than 20 minutes without any help of supervisors.
RESULTS
Both groups revealed almost the same baseline characteristics except the experience of operation. PEG 4 L group's compliance was lower than PEG 2 L with NaP 90 mL group. Success rate and cecal intubation time was not different between two groups. Overall bowel preparation quality of PEG 2 L with NaP 90 mL group was better than PEG 4 L group. Segmental bowel preparation quality of PEG 2 L with NaP 90 mL group was also better than PEG 4 L group in all segments, especially right side colon. Occurrence of hyperphosphatemia was higher in PEG 2 L with NaP 90 mL group than PEG 4 L group. However, significant adverse event was not reported.
CONCLUSIONS
PEG 2 L with NaP 90 mL method seems to be more effective bowel preparation than PEG 4 L method.

Keyword

Colonoscopy; Bowel preparation; Polyethylene glycol; Sodium phosphate

MeSH Terms

Administration, Oral
Adult
Aged
Colonic Diseases/diagnosis
Colonoscopy/*methods
Humans
Male
Middle Aged
Patient Compliance
Phosphates/*administration & dosage
Polyethylene Glycols/*administration & dosage
Questionnaires
Solutions
Therapeutic Irrigation

Figure

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  Fig. 1. Overall quality of bowel cleansing between conventional 4 L polyethylene glycol and combination of 2 L polyethylene glycol and sodium phosphate solution group in total (A), morning colonoscopy (B) and afternoon colonoscopy (C). PEG, polyethylene; NaP, sodium phosphate.

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  Fig. 2. Segmental quality of bowel cleansing between conventional 4 L polyethylene glycol and combination of 2 L polyethylene glycol and sodium phosphate solution group in total (A), morning colonoscopy (B) and afternoon colonoscopy (C).

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