Korean J Gastroenterol.  2010 May;55(5):336-339. 10.4166/kjg.2010.55.5.336.

A Case of Ulcerative Colitis Found in a Patient Whose Parent has Crohn's Disease

• Kwak JW
• Lee KM
• Chung WC
• Paik CN
• Chang UI
• Kim JD
• Jung SH
• Yang JM

• KMID: 1718340
• DOI: http://doi.org/10.4166/kjg.2010.55.5.336

Abstract

Inflammatory bowel diseases (IBD) is heterogeneous, chronic relapsing disorder. Inappropriate and exaggerated immune response for the luminal antigen is known as a main pathogenesis. Genetic, infectious, and environmental factors are responsible for unbalanced immune response, but the definite pathogenesis is still unclear. Genetic factor is the most important role of all. That is based on high concordance rate of identical twins and family history. The incident rate and prevalence of IBD for the Asian population is relatively lower than Western population, and the lack of NOD2 or TLR4 genetic polymorphisms in Korea and Japanese population suggests the difference in genetic background between Asian and Western population. In Korea, the case of familial aggregation of IBD is pretty rare. We report a case of the daughter with ulcerative colitis and her mother with Crohn's disease who have a -159C/T promoter polymorphism of CD14 gene for IBD.

Keyword

Familial aggregation; Inflammatory bowel diseases; Genetics

MeSH Terms

Antigens, CD14/genetics
Colitis, Ulcerative/*diagnosis/drug therapy/genetics
Colonoscopy
Crohn Disease/*diagnosis/genetics
Female
Genetic Predisposition to Disease
Humans
Mesalamine/therapeutic use
Middle Aged
Mothers
Polymorphism, Restriction Fragment Length
Tomography, X-Ray
Young Adult

Figure

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  Fig. 1. Abdominal CT scan. It showed long segmental circum-ferential wall thickening in the ascending colon, cecum, and terminal ileum (white arrow).

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  Fig. 2. Colonoscopic finding. (A) Ascending colon. (B) Transverse colon. It showed multiple, longitudinal ulcers covered with exudates resulting in luminal deformity.

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  Fig. 3. Colonoscopic finding. It showed diffuse mucosal edema, erythema, loss of vascularity, and scanty exudates confined to rectum.

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  Fig. 4. Genotying of the polymorphism at position -159 in the promoter of the CD14 gene. The patterns of TT homozygotes were visible in lanes 1 and 4 (M=molecular marker).

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