Korean J Intern Med.  2005 Jun;20(2):111-115. 10.3904/kjim.2005.20.2.111.

Comparison of the Clinical Features of Apical Hypertrophic Cardiomyopathy Versus Asymmetric Septal Hypertrophy in Korea

• Yang HS
• Song JK
• Song JM
• Kang DH
• Lee CW
• Hong MK
• Kim JJ
• Park SW
• Park SJ

• KMID: 1718031
• DOI: http://doi.org/10.3904/kjim.2005.20.2.111

Abstract

BACKGROUND
We sought to test whether patients with apical hypertrophic cardiomyopathy (APH) have different clinical features compared to those with typical asymmetric septal hypertrophy (ASH). METHODS: Among 32, 534 patients who underwent routine echocardiography at Asan Medical Center from January 2000 to December 2001, 305 patients (0.9%), who were finally diagnosed with hypertrophic cardiomyopathy (HCMP), were evaluated. The type of HCMP was classified according to the echocardiographic findings. RESULTS: ASH was the most frequent type (n=160, 53%, group I), and APH was the second most frequent (n=91, 30%, group II). Mean age (60.8 +/- 10 vs. 48.2 +/- 14 years, p< 0.001) and prevalence of hypertension (32% vs. 19%, p=0.022) were significantly higher in group II than in group I. Family history of HCMP (4.4% vs. 0% p=0.043) and sudden cardiac death (8.8% vs. 1.1% p=0.014) was more prevalent in group I. During the follow-up period of 32.0 +/- 37.2 months, cardiac events occurred at a significantly higher rate in group I (25.5% vs. 8.8%, p=0.003). CONCLUSION: APH comprises a significant proportion of HCMP in Korea and patients with APH show different clinical features compared to those with ASH.

Keyword

Hypertrophic cardiomyopathy; Prognosis; Echocardiography

MeSH Terms

Cardiomyopathy, Hypertrophic/epidemiology/*ultrasonography
Comparative Study
Echocardiography
Female
Follow-Up Studies
*Heart Septum/ultrasonography
*Heart Ventricles/ultrasonography
Humans
Korea/epidemiology
Male
Middle Aged
Prevalence
Retrospective Studies