Korean J Intern Med.  2009 Jun;24(2):156-159. 10.3904/kjim.2009.24.2.156.

Acute Fibrinous and Organizing Pneumonia Following Hematopoietic Stem Cell Transplantation

• Lee SM
• Park JJ
• Sung SH
• Kim Y
• Lee KE
• Mun YC
• Lee SN
• Seong CM

• KMID: 1717969
• DOI: http://doi.org/10.3904/kjim.2009.24.2.156

Abstract

A 60-year-old man presented with cough, sputum, and dyspnea. He had a history of acute myeloid leukemia and hematopoietic stem cell transplantation with chronic renal failure. Chest CT scans showed miliary nodules and patchy consolidations. Histological examination revealed numerous fibrin balls within the alveoli and thickening of the alveolar septum, both of which are typical pathological features of acute fibrinous and organizing pneumonia (AFOP). We report the first case of AFOP following allogeneic hematopoietic stem cell transplantation.

Keyword

Acute fibrinous; organizing pneumonia; Hematopoietic stem cell transplantation; Graft-versus-host disease

MeSH Terms

Acute Disease
Anti-Bacterial Agents/therapeutic use
Biopsy
Cryptogenic Organizing Pneumonia/etiology/pathology
Fatal Outcome
Glucocorticoids/administration & dosage
Hematopoietic Stem Cell Transplantation/*adverse effects
Hemoptysis/etiology
Humans
Leukemia, Myeloid, Acute/*surgery
Lung Diseases/*etiology/pathology
Male
Middle Aged
Pleural Effusion/etiology
Pulse Therapy, Drug
Radiography, Thoracic
Respiratory Insufficiency/etiology
Tomography, X-Ray Computed