Yonsei Med J.  2012 Jul;53(4):781-787. 10.3349/ymj.2012.53.4.781.

Acute Appendicitis in Children with Acute Leukemia: Experiences of a Single Institution in Korea

• Kim EY
• Lee JW
• Chung NG
• Cho B
• Kim HK
• Chung JH

• KMID: 1716878
• DOI: http://doi.org/10.3349/ymj.2012.53.4.781

Abstract

PURPOSE
Acute appendicitis has been reported to be relatively rare in pediatric leukemia patients but there is no official data for this in Korea. And there is no consensus for its treatment in this population.
MATERIALS AND METHODS
We conducted a retrospective study of 7 patients diagnosed with appendicitis among 1209 pediatric patients who were diagnosed with leukemia from 1996 to 2008 at a single institution in Korea.
RESULTS
The median age at the time of the diagnosis of appendicitis was 12 years (range: 3-15 years), and 3 of the patients were male. The median absolute neutrophil count (ANC) at the time of diagnosis was 0.99x10(9)/L (range: 0-3x10(9)/L). The mean time from the onset of symptoms to the diagnosis was 4 days. All 7 leukemia patients with appendicitis underwent surgery and they demonstrated a survival of 100% without significant complications.
CONCLUSION
The incidence of appendicitis in pediatric leukemia patients was 0.57% in our study. Early diagnosis with abdominal ultrasound or computed tomography and early surgical resection in leukemic patient with acute appendicitis may be a safer and more effective treatment option. Even when perforation has already occurred and when the patient has an ANC of 0x10(9)/L, surgical treatment may improve overall survival without incurring significant complications.

Keyword

Acute appendicitis; leukemia; neutropenia; appendectomy

MeSH Terms

Acute Disease
Adolescent
Appendectomy/adverse effects
Appendicitis/*diagnosis/surgery
Child
Child, Preschool
Female
Humans
Infant
Korea
Leukemia/*physiopathology
Male
Retrospective Studies

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