Korean J Helicobacter Up Gastrointest Res.  2012 Sep;12(3):133-140. 10.7704/kjhugr.2012.12.3.133.

Epidemiology of Adenocarcinoma of Esophagogastric Junction

• Hong JH
• Kim HS

• KMID: 1716072
• DOI: http://doi.org/10.7704/kjhugr.2012.12.3.133

Abstract

The incidence of adenocarcinoma of esophagogastric junction (AEG) has increased rapidly over the past three decades in Western countries, but data from Asian populations are conflicting. The most commonly used classification is that described by Siewert and Stein, which defines AEG as tumors that have their center within 5 cm proximal or distal to the anatomic cardia. However, there is lack of consensus in definition and classification of AEG, which has resulted in difficulties in comparing the various studies on the epidemiology of AEG. The cause of changing pattern of AEG is not clear. Known risk factors for AEG are Barrett's esophagus, gastroesophageal reflux, obesity, smoking, and medications that relax the lower esophageal sphincter. On the other hand, non-steroidal anti-inflammatory drugs (NSAIDs), Helicobacter pylori infection, fruits and vegetables, and antioxidants might reduce the risk. Currently, there is no evidence that strongly supports any strategy for surveillance of population at high risk of AEG. In Asian countries, the incidence of AEG still low, however, some countries report the increasing trend of adenocarcinoma of lower esophagus and cardia.

Keyword

Epidemiology; Adenocarcinoma of esophagogastric junction; Helicobacter pylori

MeSH Terms

Adenocarcinoma
Antioxidants
Asian Continental Ancestry Group
Barrett Esophagus
Cardia
Consensus
Esophageal Sphincter, Lower
Esophagogastric Junction
Esophagus
Fruit
Gastroesophageal Reflux
Hand
Helicobacter pylori
Humans
Incidence
Obesity
Risk Factors
Smoke
Smoking
Vegetables
Antioxidants
Smoke