Korean J Parasitol.  1998 Jun;36(2):121-125. 10.3347/kjp.1998.36.2.121.

Immunosuppressive effect of Cryptosporidium baileyi infection on vaccination against Newcastle disease in chicks

• Rhee JK
• Kim HC
• Lee SB
• Yook SY

• KMID: 1715302
• DOI: http://doi.org/10.3347/kjp.1998.36.2.121

Abstract

Hemagglutination-inhibition titers (log2) to Newcastle disease (ND) virus were chronologically observed in chicks, which were orally inoculated with 5 x 10(5) oocysts of Cryptosporidium baileyi at 2 days of age and subsequently vaccinated with inactivated ND virus at 4 and 21 days postinoculation. In general, the titers were considerably lower in the infected chicks than those in the uninfected control throughout the experimental period (p < 0.01), and rapid negative seroconversions were observed in the infected chicks. The titers reached a peak on weeks 2 and 4 post-booster-vaccination in the control and infected chicks, respectively. Thus, C. baileyi infection was shown to have an immunosuppressive effect on ND vaccination when the agent was given to 2-day-old chicks. It is suggested that C. baileyi infection in chicks may increase the host susceptibility to ND virus.

MeSH Terms

Animal
Chickens
Cryptosporidiosis/immunology*
Cryptosporidium/immunology*
Hemagglutination Inhibition Tests
Immunosuppression*
Male
Newcastle Disease/immunology*
Newcastle Disease Virus/immunology*
Viral Vaccines/immunology*