J Korean Med Sci.  2012 Aug;27(8):934-938. 10.3346/jkms.2012.27.8.934.

Influences on Formation of Tetanus Antibody after Simultaneous Injection of Tetanus Immunoglobulin with Tetanus Vaccine

• Shin J
• Kim J
• Song K

• KMID: 1714207
• DOI: http://doi.org/10.3346/jkms.2012.27.8.934

Abstract

The goal of this study was to determine how much the formation of tetanus antibody is influenced after a single injection of tetanus vaccine (Td) and the simultaneous injection of tetanus vaccine with tetanus immunoglobulin (TIG). All of the healthy adult volunteers were divided into two groups: group 1 (Td only) and group 2 (Td plus TIG). Two hundred thirty seven volunteers were enrolled. When the baseline antibody titer, gender and age were adjusted, the geometric mean titers (GMTs) of the tetanus antibody (group 1 vs group 2) was 0.8438 IU/mL vs 0.5684 IU/mL at 4 weeks (P = 0.002), 0.4074 IU/mL vs 0.3217 IU/mL at 6 months (P = 0.072) and 0.3398 IU/mL vs 0.2761 IU/mL at 12 months (P = 0.140) after injection, respectively. The formation of tetanus antibody after tetanus vaccination is not influenced by TIG at the late period and in adults below the age of 50 yr, but there are significant differences between the two groups at the early period of 4 weeks after vaccination and for the patients over 60 yr.

Keyword

Tetanus; Tetanus Toxoid; Immunoglobulins

MeSH Terms

Adult
Age Factors
Antibodies, Bacterial/blood
Female
Humans
Immunoglobulins/*administration & dosage
Male
Middle Aged
Sex Factors
Tetanus/immunology/*prevention & control
Tetanus Toxoid/*administration & dosage/immunology
Time Factors
Antibodies, Bacterial
Immunoglobulins
Tetanus Toxoid

Figure

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  Fig. 1 Comparison of the GMTs between the groups according to time after adjustment of gender and age. GMTs, geometric mean titers.

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  Fig. 2 Changes of the GMTs between the groups according to age after adjustment of gender and time. GMTs, geometric mean titers.

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