J Korean Med Sci.  2007 Feb;22(1):153-155. 10.3346/jkms.2007.22.1.153.

Gastric Accumulation of Bone Seeking Agent in a Patient with Advanced Gastric Cancer

• Kim DW
• Jeong HJ
• Park SA
• Kim CG

• KMID: 1713257
• DOI: http://doi.org/10.3346/jkms.2007.22.1.153

Abstract

Soft tissue uptake of Tc-99m labeled bone seeking agents, such as Tc-99m 3,3-diphosphono-1,2-propanedicarboxylic acid (DPD), is commonly seen in clinical practice, even though bone scintigraphy is mainly used to detect bone disease. However, gastric uptake of bone agents in patients with gastric cancer is very rare. And it has been reported that calcified gastric adenocarcinoma appears in only about 5% of all gastric cancer. We report a rare case of bone scintigraphy, single photon emission computed tomography and computed tomography fusion images that demonstrated diffuse gastric uptake of Tc-99m DPD in a patient with advanced gastric cancer.

Keyword

Radionuclide Imaging; Tomography, Emission-Computed, Single-Photon; Stomach Neoplasms

MeSH Terms

Stomach Neoplasms/*metabolism
Stomach/*metabolism
Radiopharmaceuticals/*pharmacokinetics
Organotechnetium Compounds/diagnostic use/*pharmacokinetics
Male
Humans
Diphosphonates/diagnostic use/*pharmacokinetics
Bone and Bones/*radionuclide imaging
Aged

Figure

• 

  Fig. 1 Non-contrast enhanced CT of the upper abdomen shows diffuse thickening of gastric antral wall with punctate calcifications (arrows).

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  Fig. 2 Bone scintigraphy shows increased uptake of tracer in the gastric wall (arrow) but no evidence of bone metastasis.

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  Fig. 3 The single photon emission computed tomography (SPECT) and CT fusion images show that intense Tc-99m DPD uptake is located in the anterior and posterior wall of the gastric antrum. However, the extent of tracer uptake is diffuse and broader than the gross calcifications seen on CT images.

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