J Korean Med Sci.  2007 Feb;22(1):70-73. 10.3346/jkms.2007.22.1.70.

Clinical Experience of an Iontophoresis Based Glucose Measuring System

• Rhee SY
• Chon S
• Koh G
• Paeng JR
• Oh S
• Woo JT
• Kim SW
• Kim JW
• Kim YS

• KMID: 1713232
• DOI: http://doi.org/10.3346/jkms.2007.22.1.70

Abstract

Currently finger pricking is the common method of blood glucose measurement in patients with diabetes mellitus. However, diabetes patients have proven to be reluctant to check their glucose profiles regularly because of the discomfort associated with this technique. Recently, a non-invasive and continuous Reverse Iontophoresis based Glucose Monitoring Device (RIGMD) was developed in Korea. The study was conducted during the period November 2003-January 2004 on 19 in-patients. Glucose measurements were performed using RIGMD between 10 a.m. and 4 p.m. Concurrent plasma glucose levels were checked hourly and subsequently compared with RIGMD data. The mean error of RIGMD measurements was -3.45+/-52.99 mg/dL with a mean absolute relative error of 20+/-15.16%. Measurements obtained by RIGMD were correlated with plasma glucose levels (correlation coefficient; 0.784 (p<0.05)) and this correlation was independent of time of data collection. However, after excluding confounding variables this correlation coefficient exhibited a tendency to increase. 98.9% of the results were clinically acceptable by Clarke error grid analysis. We concluded that RIGMD does not have the reliability and accuracy required to wholly replace conventional methods. However, further technical advancements that reduce its shortcomings would make this device useful for the management of diabetes.

Keyword

Iontophoresis; Blood Glucose Self-Monitoring; Diabetes Mellitus

MeSH Terms

Middle Aged
Male
Linear Models
*Iontophoresis
Humans
Female
Blood Glucose Self-Monitoring/adverse effects/*instrumentation
Aged
Adult

Figure

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  Fig. 1 Linear regression analysis result, showing the relationship between plasma glucose level and interstitial glucose level as determined by RIGMD.

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  Fig. 2 Clarke error grid analysis of plasma glucose level and interstitial glucose level by RIGMD results.

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