Korean J Parasitol.
2013 Dec;51(6):739-742. 10.3347/kjp.2013.51.6.739.
Sparganosis Presenting as Cauda Equina Syndrome with Molecular Identification of the Parasite in Tissue Sections
- Affiliations
-
- 1Division of Infectious Diseases and Tropical Medicine, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
- 2Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
- 3Division of Neurosurgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
- 4Department of Parasitology, National Institute of Infectious Diseases, Tokyo, Japan.
- 5Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. pewpan@kku.ac.th
- 6Research and Diagnostic Center for Emerging Infectious Diseases, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
- KMID: 1712230
- DOI: http://doi.org/10.3347/kjp.2013.51.6.739
Abstract
- A 52-year-old woman presented with lower back pain, progressive symmetrical paraparesis with sensory impairment, and sphincter disturbance. Magnetic resonance imaging (MRI) of the whole spine revealed multiple intradural extramedullary serpiginous-mass lesions in the subarachnoid space continuously from the prepontine to the anterior part of the medulla oblongata levels, C7, T2-T8, and T12 vertebral levels distally until the end of the theca sac and filling-in the right S1 neural foramen. Sparganosis was diagnosed by demonstration of the sparganum in histopathological sections of surgically resected tissues and also by the presence of serum IgG antibodies by ELISA. DNA was extracted from unstained tissue sections, and a partial fragment of mitochondrial cytochrome c oxidase subunit 1 (cox1) gene was amplified using a primer set specific for Spirometra spp. cox1. After sequencing of the PCR-amplicon and alignment of the nucleotide sequence data, the causative agent was identified as the larva of Spirometra erinaceieuropaei.
MeSH Terms
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Animals
Antibodies, Helminth/blood
Electron Transport Complex IV/genetics
Enzyme-Linked Immunosorbent Assay
Female
Helminth Proteins/genetics
Histocytochemistry
Humans
Immunoglobulin G/blood
Magnetic Resonance Imaging
Middle Aged
Molecular Sequence Data
Polyradiculopathy/*pathology
Sequence Analysis, DNA
Sparganosis/*diagnosis/*pathology
Spine/radiography
Spirometra/classification/genetics/*isolation & purification
Antibodies, Helminth
Electron Transport Complex IV
Helminth Proteins
Immunoglobulin G
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