J Prev Med Public Health.
2013 Sep;46(5):271-281.
A Prospective Cohort Study on the Relationship of Sleep Duration With All-cause and Disease-specific Mortality in the Korean Multi-center Cancer Cohort Study
- Affiliations
-
- 1Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea. kyyoo@snu.ac.kr
- 2Cancer Research Institute, Seoul National University, Seoul, Korea.
- 3Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea.
- 4Department of Preventive Medicine, Konkuk University, Seoul, Korea.
- 5Non-communicable Disease and Health Promotion, Western Pacific Regional Office, World Health Organization, Manila, Philippines.
Abstract
OBJECTIVES
Emerging evidence indicates that sleep duration is associated with health outcomes. However, the relationship of sleep duration with long-term health is unclear. This study was designed to determine the relationship of sleep duration with mortality as a parameter for long-term health in a large prospective cohort study in Korea.
METHODS
The study population included 13 164 participants aged over 20 years from the Korean Multi-center Cancer Cohort study. Information on sleep duration was obtained through a structured questionnaire interview. The hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality were estimated using a Cox regression model. The non-linear relationship between sleep duration and mortality was examined non-parametrically using restricted cubic splines.
RESULTS
The HRs for all-cause mortality showed a U-shape, with the lowest point at sleep duration of 7 to 8 hours. There was an increased risk of death among persons with sleep duration of < or =5 hours (HR, 1.21; 95% CI, 1.03 to 1.41) and of > or =10 hours (HR, 1.36; 95% CI, 1.07 to 1.72). In stratified analysis, this relationship of HR was seen in women and in participants aged > or =60 years. Risk of cardiovascular disease-specific mortality was associated with a sleep duration of < or =5 hours (HR, 1.40; 95% CI, 1.02 to 1.93). Risk of death from respiratory disease was associated with sleep duration at both extremes (< or =5 and > or =10 hours).
CONCLUSIONS
Sleep durations of 7 to 8 hours may be recommended to the public for a general healthy lifestyle in Korea.
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