J Vet Sci.  2013 Jun;14(2):215-222. 10.4142/jvs.2013.14.2.215.

Effects of one-time and two-time intra-articular injection of hyaluronic acid sodium salt after joint surgery in dogs

• Nganvongpanit K
• Boonsri B
• Sripratak
• Markmee P

• KMID: 1705524
• DOI: http://doi.org/10.4142/jvs.2013.14.2.215

Abstract

Thirty-one dogs with patellar luxation (grades 2 and 3) were categorized into three groups. Group 1 (G.1; n = 12) had sodium hyaluronate (SHA) intra-articularly injected into the stifle joint that received surgery. Group 2 (G.2; n = 10) received SHA twice: first after surgery and then 1 week later. Group 3 (G.3; n = 9) served as a control, without injection. Blood was collected before injection and then once a week for 4 weeks after injection for evaluation of chondroitin sulfate (CS-WF6) and hyaluronan (HA). The results revealed significantly (p < 0.05) improved clinical scores by the end of week 4 in G.1 and G.2 relative to G.3; however, there was no significant difference between G.1 and G.2. There was a significant decrease (p < 0.05) in serum CS-WF6 levels beginning at week 2 in G.1 and G.2. At weeks 3 and 4, serum HA in G.1 and G.2 differed from that in G.3 (p < 0.05). No significant difference (p > 0.05) was observed in serum biomarkers between G.1 and G.2. In conclusion, intra-articular injection with SHA after joint surgery may improve homeostasis of the joint, retarding the process of OA.

Keyword

biomarker; dog; joint surgery; osteoarthritis; sodium hyaluronate

MeSH Terms

Animals
Blood Chemical Analysis/veterinary
Chondroitin Sulfates/metabolism
*Dogs
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay/veterinary
Female
Hyaluronic Acid/*administration & dosage/metabolism
Injections, Intra-Articular/veterinary
Male
Osteoarthritis, Knee/drug therapy/prevention & control/*veterinary
Stifle/*surgery
Viscosupplements/*administration & dosage
Chondroitin Sulfates
Hyaluronic Acid
Viscosupplements

Figure

• 

  Fig. 1 Mean (±SD) score of weight-bearing, lameness, and pain on palpation. Values with different superscripts (a, b) are significantly different (p < 0.05) when compared in the same week.

• 

  Fig. 2 Mean (±SD) of relative change (%) of serum chondroitin sulfate epitope WF6 (CS-WF6) and hyaluronan (HA). Values with different superscripts (a, b) are significantly different (p < 0.05) when compared in the same week.

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