J Clin Neurol.  2007 Mar;3(1):57-61. 10.3988/jcn.2007.3.1.57.

Striopallidodentate Calcification and Progressive Supranuclear Palsy-Like Phenotype in a Patient with Idiopathic Hypoparathyroidism

• Kim TW
• Park IS
• Kim SH
• Lee KS
• Kim YI
• Kim JS

• KMID: 1700689
• DOI: http://doi.org/10.3988/jcn.2007.3.1.57

Abstract

We present a 77-year-old woman with levodopa-nonresponsive parkinsonism, dementia, and supranuclear gaze palsy on vertical and horizontal gaze. Laboratory findings were consistent with idiopathic hypoparathyroidism, and brain computed tomography showed extensive bilateral calcifications of the basal ganglia, centrum semiovale, dentate nuclei, and cerebellar white matter. These results illustrate that striopallidodentate calcification due to hypoparathyroidism may present with symptoms mimicking progressive supranuclear palsy.

Keyword

Striopallidodentate calcification; Idiopathic hypoparathyroidism; Progressive supranuclear palsy

MeSH Terms

Aged
Basal Ganglia
Brain
Dementia
Female
Humans
Hypoparathyroidism*
Paralysis
Parkinsonian Disorders
Phenotype*
Supranuclear Palsy, Progressive

Figure

• 

  Figure 1 Computed tomography (CT) of the brain demonstrated extensive, bilateral calcification of the basal ganglia, centrum semiovale, and bilateral dentate nuclei of the cerebellum (A). Magnetic resonance imaging revealed mixed high- and low-intensity signals compatible with the distribution of calcification on CT. The red nucleus and substantia nigra appeared normal (B).

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