J Korean Pediatr Soc.  1982 Jun;25(6):554-559.

The Effects of Phenobarbital and Theophylline on the Phagocytic Function of Reticuloendothelial System of Rats

• Cho SC
• Lee HS
• Kim KC
• Choi HY

Abstract

This experiment was carried out to investigate the effects of depressor and stimulator of central nervous system on the reticuloendothelial phagocytic function in vivo. The phagocytic activity was assessed by means of carbon clearance method after intra-muscular adimnistration of phenobarbital(1mg/0.2 ml of normal saline/100 gm of body weight) and intravenous administ-ration of theophylline(1 mg/0.2 ml of normal saline/100 gm of body weight) into rats. The obtained results were as follows; 1. In the groups administrered with phenobarbital, the alteration in the phagocytic activity wi-thin three hours after administration was decreased compared with the normal and control gro-up, but thereafter, it was increased progressively to the normal level by 12 hours after administr-ation. 2. In the groups administered with theophylline, the alteration in the phagocytic activity within one hour after adminstration was increased compared with normal and control group, but after that decreased gradually to the normal level by 12 hours after injection. 3. From these results, it is concluded that stimulation of central nervous system may increa-se the phagocytic activity and depression of central nervous system may decrease the phagocy-tic activity of reticuloendothelial system.

Keyword

Pathophysiology of RES

MeSH Terms

Animals
Carbon
Central Nervous System
Depression
Mononuclear Phagocyte System*
Phenobarbital*
Rats*
Theophylline*
Carbon
Phenobarbital
Theophylline