J Korean Neurol Assoc.  1992 Dec;10(4):554-558.

A Case of McArdle's Disease

• Lee SI
• Song CW
• Park KH
• Kim SW

Abstract

McArdle's disease is a disorder of carbohydrate metabolism, which is inhented as an autosomal recessive or occasionally an autosomal dominant trait. Hallmark of clinical features is exercise intolerence, I.e. muscle pain following strenuous exercise. Electrophysiologically insertion of an EMG needle shows that there is no electrical activity, differentiating this contracture from a muscle cramp. Histological examination of muscle biopsy specimen shows increase in glycogen and the presence of subsarcolemrnal blebs. We report a 23-year-old, male patient who presented clinical, electrophysiological, and histological findings compatible with McArdle's disease.

MeSH Terms

Biopsy
Blister
Carbohydrate Metabolism
Contracture
Glycogen
Glycogen Storage Disease Type V*
Humans
Male
Muscle Cramp
Myalgia
Needles
Young Adult
Glycogen