Korean J Neuromuscul Disord.  2021 Dec;13(2):55-58. 10.46518/kjnmd.2021.13.2.55.

A Case of Glycogen Storage Disease Type V with Rhabdomyolysis after COVID-19 Vaccination

• Kim H
• Kim Ye
• Lee HL

• KMID: 2523956
• DOI: http://doi.org/10.46518/kjnmd.2021.13.2.55

Abstract

Glycogen storage disease (GSD) type V, also known as McArdle’s disease, is an autosomal recessive genetic disease caused by a mutation of the PYGM gene related to the synthesis of the myophosphorylase enzyme. Here, we presented the case of an 83-year-old woman who was admitted for progressively worsening weakness of her legs due to rhabdomyolysis after a COVID-19 vaccination. In the muscle biopsy, myopathy with subsarcolemmal glycogen accumulation was revealed and she was diagnosed with a mild form of GSD type V. Although COVID-19 vaccines are generally safe and encouraged for everyone, adverse events following COVID-19 vaccinations are increasing. We should pay attention to the side effects of COVID-19 vaccination including rhabdomyolysis.

Keyword

Glycogen storage disease type V, Rhabdomyolysis, COVID-19 vaccine