Korean J Dermatol.  1982 Aug;20(4):519-523.

Topographic Variance of Contact Sensitivity Reaction in Guinea Pig

• Kim JW
• Houh W

Abstract

There have been published manuscripts which fully suggest that there may be a topographic variance of contact sensitivity in experimental animals such as guinea pigs, hamsters and mice, probably due to a large extent to the topographic difference of Langerhans cell population and to a little extent to impact on the induction site. This assay was done to establish the possibility of involvement of a certain topographic variance in contact sensitivity reaction. Three different anatomical sites were chosen for the induction in three groups of five guinea pigs: the conventional site of the nuchal region, and the sacral aod. ahdominal skin regions. For the elicitation, two different concentrations of DNCB were applied on three sites along both sides of the spine in the back. The contact sensitivity reaction elicited by DNCB in the group of the nuchal abdominal skin induction was definitely stronger at the site closer to the nuchal region than that found at sites closer to the sacral regior. but all animals of the group sensitized on the sacral region showed comparatively uniform reaction. Zvidently, contact sensitivity reaction is influenced mainly by topographic variance hut shows a litte difference depending upon induction sites.

MeSH Terms

Animals
Cricetinae
Dermatitis, Contact*
Dinitrochlorobenzene
Guinea Pigs*
Guinea*
Mice
Sacrococcygeal Region
Skin
Spine
Dinitrochlorobenzene