J Korean Ophthalmol Soc.  1968 Jun;9(2):13-18.

Effects of the Antihypertensive Drugs on the Choroidal Blood Flow in Rabbits

• Kang NY
• Youn WS

Abstract

The effects of antihypertensive drugs on the choroidal blood flow in rabbits were studied by an apparatus based on the principle of internal calorimetry of Grayson. Thermistors, as the sensing elements, were fastened on the scleral surface of the eye, and determinations were performed up to 60 minutes after intravenous administrations of drugs. The drugs studied were: ganglion blocking agents (pentholinium tartarate, 4 mg; hexamethonium bromide, 1 mg; and mecamylamine chloride, 0.15mg), alpha-methyldopa, 4 mg; guanethidine, 0.5 mg; reserpine, 0.2 mg; hydralazine, 5 mg; and diuretics (dichlorothiazide, 2.5 mg; frusemide, 2.5 mg). Except the diuretics, all the drugs employed produced considerable increase in the choroidal blood flow. The relationships between blood pressure, intraocular pressure and the choroidal blood flow were discussed and the clinical applications were suggested.

MeSH Terms

Administration, Intravenous
Antihypertensive Agents*
Blood Pressure
Calorimetry
Choroid*
Dental Calculus
Diuretics
Furosemide
Ganglion Cysts
Guanethidine
Hexamethonium
Hydralazine
Intraocular Pressure
Mecamylamine
Methyldopa
Rabbits*
Reserpine
Antihypertensive Agents
Diuretics
Furosemide
Guanethidine
Hexamethonium
Hydralazine
Mecamylamine
Methyldopa
Reserpine