Korean J Dermatol.  1970 Jan;8(1):3-9.

Effect of Some Immunosuppressive Agents on the Survival of Experimental Skin Homografts in Rats I. Effect of Total Body Irradiation, Imuran, Prednisolone and Splenectomy

• Kim WS
• Lim SD
• Kim HS

Abstract

Several immunosuppressive agents were used to prolong the survival of full-thickries skin homografts in albino rats. The grafts were squares in size of 2.0cm. The results were as follows. 1. The mean survival time of skin homografts in control group was 6.0 days. 2. Total body X-irradiation (500r) to the recipients 24 hours before grafting resulted in prolongation of survival of the grafts. (Mean, 12.5 days) 3. Administration of Imuran(azathioprine) to the recipients in a does of 5mg/kg/day for 7 days. before grafting resulted in prolongation of survival of the grafts. (Mean, 9. 6 days) 4. Spleneetomized homografted rats showed no prolongation of survival of the grafts. (Mean, 6.1days) 5. Administration of prednisolone to the recipients in a does of 2mg/kg/day for 7 days before grafting resulted in no prolongation of survival of the grafts. (Mean, 6.3 days) 6. Above results were discussed and compared with those of others.

MeSH Terms

Allografts*
Animals
Azathioprine*
Immunosuppressive Agents*
Prednisolone*
Rats*
Skin*
Splenectomy*
Survival Rate
Transplants
Whole-Body Irradiation*
Azathioprine
Immunosuppressive Agents
Prednisolone