Korean J Anesthesiol.  1969 Jan;2(1):29-33.

Effect of Small Dose Atropine on Cardiac Rate in Rabbits

• Choi SH

Abstract

In rabbits: (1) Intravenous atropine in the dose of 0.002-0.004 mg/kg caused bradycardia, whereas in that exceeding 0.02 mg/kg tachycardia. Transient but alarming degrees of tachycardia could be observed when 2 mg/kg dose was employed. (2) While Arfonad was being infused, the heart rate changed little regardless of the doses of atropine used. (3) During Arfonad drip, changes in heart rate seemed fairly well correlated with the degree of hypotension, i.e., magnitude of ganglionic blookade. (4) The above findings suggest that, at least in rabbits, small dose atropine-induced cardiac slowing is due to the inhibitory action of atropine on the sympathetic ganglia. This cannot, however, be directly applied to human physiology because of the possible species difference in the regulatory mechanisms of heart rate.

MeSH Terms

Atropine*
Bradycardia
Ganglia, Sympathetic
Ganglion Cysts
Heart Rate
Humans
Hypotension
Physiology
Rabbits*
Tachycardia
Atropine