J Korean Soc Pediatr Nephrol.  2005 Oct;9(2):167-174.

Predictive Factors for Relapse in Children with Steroid Responsive Nephrotic Syndrome

• Cho MH
• Lee DW
• Lee TH
• Ko CW

Abstract

PURPOSE: Relapses are a major problem in children with steroid responsive nephrotic syndrome(SRNS). This study has been performed to determine the predictive factors for relapse in children with SRNS.
METHODS
The study group consisted of 73 children with SRNS who had been admitted to the Department of Pediatrics, Kyungpook National University Hospital, over 6 years from 1996 to 2001. The medical records were reviewed retrospectively and analyzed to determine significant relationships between selected variables[age at onset, sex, laboratory data, the rapidity of response(days to remission), interval to first relapse] and the frequency of relapse.
RESULTS
The age(mean+/-SD) of patients was 4.53+/-2.53 years old. The male to female ratio was 52:21. In 95%, 39 out of the 41 children had a renal biopsy, and the final diagnosis was minimal change nephrotic syndrome. There was no significant correlation between the frequency of relapse and the following variables:age at onset, sex, and presence of hematuria. However, the rapidity of response correlated well with the frequency of relapse, especially during the first year after the onset of the disease(P=0.006).
CONCLUSION
The rapidity of response is expected to be one of the predictive factors for relapse in children with SRNS.

Keyword

Steroid responsive nephrotic syndrome; Predictive factors; Relapse

MeSH Terms

Biopsy
Child*
Diagnosis
Female
Gyeongsangbuk-do
Hematuria
Humans
Male
Medical Records
Nephrosis, Lipoid
Nephrotic Syndrome*
Pediatrics
Recurrence*
Retrospective Studies