Korean J Med.  2003 Aug;65(2):205-214.

Relationship between estrogen receptor thymine-adenine repeat polymorphism and effects of hormone replacement therapy on serum lipid and bone density in postmenopausal women

• Yim CH
• Hwang CS
• Kang YS
• Moon IK
• Kim SH
• Chung HY
• Han KO
• Jang HC
• Park WK
• Yoon HK
• Han IK
• Park YS
• Kim DS
• Ahn YH
• Kim TH

Abstract

BACKGROUND: Several biologically plausible mechanisms have been proposed for estrogen-associated changes in lipid and bone metabolism. These effects are thought to be mediated via estrogen receptor (ER). Several polymorphisms in the gene encoding estrogen receptor alpha may modify the effects of hormone replacement therapy on lipid and bone density in postmenopausal women.
METHODS
We examined 284 postmenopausal women for thymine-adenine (TA) repeat polymorphism at the ER gene locus and its relationship to lipid and bone density. Their mean age was 52.2+/-5.0 years. We also investigated the association between ER TA repeat polymorphism and changes in lipid and bone density after 3 months and 1 year of hormone replacement therapy.
RESULTS
According to the mean number of TA repeats, the women were divided into two groups: group H, with higher number of repeats (TA>16)(n=110); group L, with lower number of repeats (TACONCLUSION
These data suggest that ER TA repeat polymorphism may be one of the predictors of lipid response to hormone replacement therapy.

Keyword

Estrogen receptors; Polymorphism; Hormone replacement therapy; Lipids; Bone density

MeSH Terms

Bone Density*
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Estrogen Receptor alpha
Estrogens*
Female
Hormone Replacement Therapy*
Humans
Metabolism
Receptors, Estrogen
Triglycerides
Cholesterol
Cholesterol, HDL
Cholesterol, LDL
Estrogen Receptor alpha
Estrogens
Receptors, Estrogen