Korean J Gastroenterol.  2002 Jan;39(1):33-39.

Prognostic Factors after Hepatic Resection of Hepatocellular Carcinoma: Univariate and Multivariate Analysis

• Park CK
• Jang WY
• Lee JI
• Song SY
• Choi MS
• Cho JW
• Kim SW

Abstract

Background/Aims: We assessed prognostic factors affecting cumulative survival rate and recurrence-free survival rate after hepatic resection of hepatocellular carcinoma (HCC).
Methods
Univariate and multivariate analyses were performed in 108 consecutive patients with HCC who underwent curative hepatic resection between November 1994 and March 1998.
Results
The cumulative survival rates were 89.8%, 75.5%, and 56.6% at 1, 3, 5 years, respectively. The cumulative recurrence-free survival rates were 78.9%, 62.1%, and 53.0% at 1, 3, 5 years, respectively. The patients who had preoperative serum alphaFP 20 ng/mL showed high cumulative recurrence-free survival rates in univariate (p=0.020) and multivariate (p=0.061) analysis. Single tumor was associated with increased cumulative survival rates (p=0.034) and cumulative recurrecne-free survival rates (p=0.029) in multivariate analysis. The presence of tumor capsule was associated with increased cumulative recurrence-free survival rates in univariate (p=0.031) and multivariate (p=0.030) analysis.
Conclusions
By these results, resection alone is unlikely to cure HCC patients with multiple tumors or no tumor capsule. Preoperative serum alphaFP level may be of prognostic significance in patients with HCC.

Keyword

Hepatocellular carcinoma; Prognostic factors; Recurrence; Survival

MeSH Terms

Carcinoma, Hepatocellular*
Humans
Multivariate Analysis*
Recurrence
Survival Rate