Korean J Obstet Gynecol.  2005 Jun;48(6):1533-1539.

A Successful Surrogate Pregnancy in a Patient with Mayer-Rokitansky-Kuster-Hauser Syndrome

• Han MY
• Heo IJ
• Park HJ
• Lee HJ
• Lee EH

Abstract

Lack of mullerian development (Mayer-Rokitansky-Kuster-Hauser Syndrome) is characterized by absence of apparent vagina and/or uterus, normal secondary sexual characteristics, normal reproductive hormonal profile, and a relatively common cause of primary amenorrhea about 1 in 4,000 female births and also cause of primary infertility. Management for these women comprise of construction of neovagina for sexual life. In 1985, the first report of a successful pregnancy through the uterine surrogacy was made. It is being possible for these women to have new opportunity of getting her own genetic offspring. Since ovarian activity is completely preserved in patients, controlled ovarian hyperstimulation is similar to any other IVF case that is with urinary or recombinant gonadotropins following GnRH agonist down regulation. Genetic offspring can be achieved by cellection of oocytes from the genetic mather, in-vitro-fertilization by the genetic father, and placement into a surrogate carrier. We have experienced a case of successful surrogate pregnancy in a patient with congenital absence of vagina and uterus.

Keyword

Mayer-Rokitansky-Kuster-Hauser Syndrome; Surrogate pregnancy

MeSH Terms

Amenorrhea
Down-Regulation
Fathers
Female
Gonadotropin-Releasing Hormone
Gonadotropins
Humans
Infertility
Oocytes
Parturition
Pregnancy*
Uterus
Vagina
Gonadotropin-Releasing Hormone
Gonadotropins