J Korean Rheum Assoc.  2005 Mar;12(1):12-17.

Clinical Significance of Autoantibodies to Glucose-6-Phosphate Isomerase in Synovial Fluid of Patients with Rheumatoid Arthritis

• Kim SH
• Kim SD
• Kim HR
• Park SH
• Kim HY

Abstract

OBJECTIVE
Autoantibody against glucose-6-phosphate isomerase (GPI) has been shown to be present in both the serum and synovial fluid (SF) of patients with rheumatoid arthritis (RA). The purpose of this study was to evaluate whether GPI serves as a specific autoantigen in the SF of patients with RA and to investigate the relationship of anti-GPI antibody with clinical parameters of RA.
METHODS
SF was collected from 34 patients with RA and 34 patients with osteoarthritis (OA). The samples were tested by enzyme-linked immunosorbent assay (ELISA) using human recombinant GPI as antigen. Patients with RA were classified according to rheumatoid factor (RF) positivity, the presence of RA shared epitope, the presence of extraarticular manifestations, and evidence of bony erosive changes. RESUTLS: SF levels of anti-GPI antibody were higher in patients with RA than in patients with OA (631.12+/-534.02 AU versus 112.38+/-90.45 AU, p<0.001). In RA, there was no significant difference in SF anti-GPI antibody levels according to RF positivity, the presence of extraarticular manifestations, and evidence of bony erosive changes.
CONCLUSION
Autoantibodies to GPI in SF have more related with patients with RA compared with those with OA. In patients with RA, autoantibodies to GPI in SF are not associated with the poor prognostic factors and disease activity of RA.

Keyword

Anti-GPI antibody; Rheumatoid Arthritis

MeSH Terms

Arthritis, Rheumatoid*
Autoantibodies*
Enzyme-Linked Immunosorbent Assay
Glucose-6-Phosphate Isomerase*
Glucose-6-Phosphate*
Humans
Osteoarthritis
Rheumatoid Factor
Synovial Fluid*
Autoantibodies
Glucose-6-Phosphate
Glucose-6-Phosphate Isomerase
Rheumatoid Factor