Korean J Cerebrovasc Surg.
2004 Mar;6(1):11-15.
Hemodynamic Pathogenesis of AVM
- Affiliations
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- 1Department of Neurosurgery, Soonchunhyang University Hospital, Bucheon, Korea. bumtkim@sch.ac.kr
Abstract
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Significantly decreased perfusion pressure is common in vascular territories irrigating neuronal tissue in patients with AVMs. There is evidence that "adaptive autoregulatory displacement" occurs in these patients which maintains cerebral blood flow above ischemic levels. Chronic arteriolar vasodilatation does not usually lead to vasomotor paralysis because most patients maintain a constant cerebral blood flow
in spite of increased systemic arterial pressure. AVM hemodynamics appears to play an important role in the etiology of spontaneous intracerebral hemorrhage. Large AVM with high-flow and severe arterial hypotension are least likely to hemorrhage. In patients with AVMassociated aneurysm, the etiology of these dual lesions is likely multifactorial, with hemodynamic stresses having a dominant influence.