J Korean Radiol Soc.  2006 Feb;54(2):69-77. 10.3348/jkrs.2006.54.2.69.

Usefulness of Perfusion CT in Progressive Massive Fibrosis

• Kwon W
• Lee YH
• Lee MS
• Kim YJ
• Sung KJ
• Kim MS
• Yong SJ
• Jung SH

• KMID: 1577147
• DOI: http://doi.org/10.3348/jkrs.2006.54.2.69

Abstract

PURPOSE: We wanted to evaluate the usefulness of perfusion CT for the diagnosis of progressive massive fibrosis.
MATERIALS AND METHODS
We retrospectively analyzed the perfusion CT images of 20 lesions that showed progressive massive fibrosis in 13 patients. Using 16 channel multi-detector CT, a dynamic study was performed with the multiple spiral acquisition technique at 0 (precontrast), 15, 30, 45, 60, 90, 120, 180, and 300 seconds after contrast injection. The perfusion image was reformatted using these source images; it was scored on the volume map and washout map by visual inspection and then compared with 20 lesions of lung cancer.
RESULTS
The volume map showed either middle or low perfusion for 19 among the 20 lesions. The washout map also showed a weak or moderate washout pattern. The kappa values (>0.818) for the inter-reader agreement reached statistical significance (p<0.01). High perfusion on the volume map was seen in 1 case (5%) in the PMF group and in 19 cases (95%) in the lung cancer group. Intense washout on the washout map was seen in 1 case (5%) in the PMF group and in 14 cases (70%) in the lung cancer group. There was a significant difference between the two groups (x2=32.129, p<0.01).
CONCLUSION
Perfusion CT consisting of the volume map and washout map can be a useful method for the differential diagnosis between PMF and lung cancer.

Keyword

Lung, CT; Pneumoconiosis; Perfusion

MeSH Terms

Diagnosis
Diagnosis, Differential
Fibrosis*
Humans
Lung Neoplasms
Perfusion*
Pneumoconiosis
Retrospective Studies