Korean J Anat.
2002 Feb;35(1):91-97.
Increased Expression of Tenascin on Photodamaged Vitiligo Skin
- Affiliations
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- 1Department of Anatomy, College of Medicine Kyunghee University, Korea. hakbeom@hananet.net
- 2Department of Anatomy, Gachon Medical School, Korea.
- 3Department of Preventive Medicine, Gachon Medical School, Korea.
- 4Department of Dermatology, College of Medicine Kyunghee University, Korea.
Abstract
- Tenascin is suggested the one of cause of vitiligo by interfering melanocyte adhesion and migration. The distribution and expression levels of tenascin were examined by semiquantitative immunohistochemistry on skin biopsies from vitiligo patients with varying area of photodamage. The level of tenascin on adult skin is severely restricted but we had observed the increase on vitiligo skin lesions. Although it is uncertain that the increased tenascin expression is the cause or the result of disease, vitiligo and increased tenascin expression is thought to be related each other. This study has shown that tenascin increased on photodamaged vitiligo skin lesions. So we shoud consider choosing phototherapy to vitiligo.
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