Squamous Cell Carcinoma of the Liver after Choledochal Cystectomy

Song, Ho June; Seog, Woong; Woo, Gwang Hoon; Lee, June Sung; Yoon, Jung Hwan; Lee, Hyo Suk; Yoon, Yong Bum; Kim, Chung Yong

Abstract

Since it was reported in 1944 that choledochal cyst could convert into cancer, there have been many studies and reports about the malignant conversion of choledochal cyst. The most common pathologic type of associated cancers is adenocarcinoma, and squamous cell carcinoma accounts for 4.8% of all associated cancers. Recently, we experienced an uncommon case of squamous cell carcinoma of the liver arising in a 16-year-old female, who had received choledochal cystectomy and choledochojejunostomy because of type IV choledochal cyst at 12 years of age. The abdominal computerized tomography scan showed a large (6 cm), ill-defined, low attenuated intrahepatic mass with peripheral bile duct dilatation. Ultrasonography-guided liver biopsy revealed squamous cell carcinoma with intercellular bridges. We report the first case of squamous cell carcinoma of the liver associated with choledochal cyst in Korea. At the time of diagnosis, it was centrally located and far advanced, invading portal vein. She died 3 months later.