J Korean Acad Oral Maxillofac Radiol.  1998 Feb;28(1):285-297.

Failure Of Odontogenesis After Chemo-Radiation Therapy For Rhabdomyosarcoma

• Choi SY
• Hong SW
• Koh KJ

Abstract

This report details a case of 8-year-old girl showing failure of odontogenesis after chemo-radiation therapy for rhabdomysarcoma at the age of 4. The observed results were as follows ; 1. Past history revealed that she had received for a total radiation dose od 4430cGy, 29 fractions in 6 weeks and chemotherapy with vincristine, actinomycin D and cytoxan, followed as maintenance phase for 2 years. 2. The patient was symptom-free and appointed for the treatment of multiple dental caries. 3. Oral examination showed hypoplastic enamel on whole erupted permanent teeth and showed retarded eruption. 4. Conventional radiograms showed failure of root development including abrupt cessation of root formation and root agenesis, and microdobtia, missing teeth, irregular enamel, dislocation of the impacted teeth. Additional finding showed good healing bone pattern on the left mandibular ramus and angle area. 5. Cehalometric analysis revealed failure of bite raising due to incomplete eruption of all the first molars and made it possible to suspect entrapped mandibular growth and then Class II tendency growth. 6. There was correlation between the time of chemo-radiation therapy and the damage of the teeth.

MeSH Terms

Child
Cyclophosphamide
Dactinomycin
Dental Caries
Dental Enamel
Dental Enamel Hypoplasia
Diagnosis, Oral
Dislocations
Drug Therapy
Female
Humans
Molar
Odontogenesis*
Rhabdomyosarcoma*
Tooth
Tooth, Impacted
Vincristine
Cyclophosphamide
Dactinomycin
Vincristine