Korean Lepr Bull.  2003 Jul;36(1):27-34.

Evaluation of an Immunochromatography Assay Kit for the Detection of Antibodies to the Mycobacterium leprae-specific Phenolic Glycolipid-I Antigen

• Kim JP
• Cho SN
• Ko YH

Abstract

Among the many reported applications of the detection of antibodies to phenolic glycolipid-I (PGL-I) of Mycobacterium leprae, the use of seroprevalence as an indicator of the magnitude of the leprosy problem may turn out to be very useful in leprosy control programs. In order to facilitate the use of PGL-I based serology in leprosy control programs, however, a simple test system for the detection of antibodies to PGL-I has been required. For being searched the meaning of qualitative analysis for PGL-I antibodies, we examined enzyme-linked immunosorbent assay and immunochromatographic assay kit using PGL-I neoglycoconjugate antigens. The sensitivity was 91.7%, and the specificity was 78.1%.

Keyword

leprosy; phenolic glycolipid-I; immunochromatographic assay; serodiagnosis

MeSH Terms

Antibodies*
Enzyme-Linked Immunosorbent Assay
Immunochromatography*
Leprosy
Mycobacterium leprae
Mycobacterium*
Phenol*
Sensitivity and Specificity
Seroepidemiologic Studies
Serologic Tests
Antibodies
Phenol