Korean J Blood Transfus.  2007 Aug;18(2):116-120.

No Hemolytic Transfusion Reactions in a Patient with the Apparent Anti-e Autoantibody Following Transfusion of Packed Red Cells with CcDEe Phenotype

• Yun HK
• Cho D
• Chae MJ
• Jeon MJ
• Suh SP
• Ryang DW

Abstract

Patients with alloantibody should be transfused with specific antigen negative blood, and in the case of autoantibody, the least incompatible blood on crossmatching can be transfused. Yet any transfusion cases that possessed autoantibody with the apparent antigen specificity have been rarely reported. A 62 year-old-woman with chronic renal failure underwent tests showing that the direct antiglobulin test was positive (2+) for IgG, the autocontrol test was positive, and the Rh phenotype of her erythrocytes was typed as group CcDEe. One unit of the e-positive packed red cells (PRCs) was transfused before an antibody identification test identified this antibody as autoantibody with an apparent e antigen specificity, but the level of hemoglobin increased from 6.3 g/dL to 7.4 g/dL without a hemolytic reaction or other transfusion side-effects.

Keyword

Autoimmune hemolytic anemia; Autoanti-e; Rh mimicking antibody

MeSH Terms

Anemia, Hemolytic, Autoimmune
Blood Group Incompatibility*
Coombs Test
Erythrocytes
Humans
Immunoglobulin G
Kidney Failure, Chronic
Phenotype*
Sensitivity and Specificity
Immunoglobulin G